HGI has been criticized because (1) as ‘big science’ with top down administration it seems to squeeze out local initiative by smaller laboratories and (2) the large financial investment in genome mapping and sequencing leaves little funds left over for other worthy research projects. "The genome project has been overhyped and oversold," complains Boston University School of Medicine health law professor George J. Annas, who then adds, "it is the obligation of those who take legal and ethical issues seriously to insure that the dangers, as well as the opportunities, are rigorously and publicly explored." Who’s Afraid of the Human Genome?’ Hastings Center Report, 19:4 (July-August, 1989) 21.

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